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抗抑郁药对患有抑郁和焦虑症的患者的射精功能障碍的影响:系统性审查和网络元分析

Qihua Wang¹, Zhunan Xu¹, Xiangyu Chen¹

¹Department of Urology, Tianjin Medical University General Hospital, Tianjin, China.

|September 30, 2024

概括

一些抗抑郁药会引起性副作用,如射精功能障碍 (EjD). 特拉佐,沃尔蒂奥克塞丁,维拉佐和阿戈梅拉丁是安全的替代品,性功能障碍的风险较低.

科学领域:

精神病学是一个精神病学.
药理学药理学是指药理学的学科.
临床研究临床研究

背景情况:

抗抑郁药与性不良反应 (SAE) 有关,包括射精功能障碍 (EjD),这往往是被忽视的.
了解不同抗抑郁药的EjD比较发病率对于有效的治疗选择和患者管理至关重要.

研究的目的:

进行网络元分析,比较和排名各种抗抑郁药物中EjD的发病率.
为临床医生提供基于证据的指导,用于管理抗抑郁药引起的性功能障碍和优化药物选择.

主要方法:

在主要数据库 (PubMed,Embase,Scopus,Web of Science,ClinicalTrials.gov) 进行了系统的文献搜索.
包括符合条件的随机对照试验 (RCT),比较患有严重抑郁症 (MDD) 和焦虑症患者的抗抑郁药EjD率.
患EjD,勃起功能障碍 (ED),性欲下降 (DL) 和其他不良事件的发病率使用几率比率 (OR) 和置信区间 (CI) 进行了聚合;使用积累排名曲线 (SUCRA) 下面表面值进行排名.

主要成果:

分析了30个涉及18,157名患者的RCT,没有发现统计不一致性.
与安慰剂相比,克洛米胺,WS5570和帕洛克塞丁显示出EjD的风险明显更高.
zodone,vilazodone和vortioxetine在EjD,ED和DL方面表现出良好的安全性,而vilazodone在不良事件和戒断指标上表现良好.

结论:

推Trazodone,vortioxetine,vilazodone和agomelatine作为替代性抗抑郁药物,用于患有性不良反应的患者.
与某些其他抗抑郁药相比,这些药物似乎对EjD和其他性功能障碍的发病率较低.

关键词:

抗抑郁药是一种抗抑郁药.焦虑是一种焦虑.抑郁抑郁症抑郁症抑郁症是一种射精射精是什么意思射精射精是什么意思上腺素再吸收抑制剂上腺素再吸收抑制剂选择性血清素再吸收抑制剂选择性血清素再吸收抑制剂血清胺 (serotonin) 是一种神经元.

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