耐力运动员的高密度胆固醇 (HDL) 构成有利,与高密度胆固醇在体外抗氧化和内皮抗炎功能的变化无关
Jack David Beazer1, Anne Sillars1, Sally Beck1
1School of Cardiovascular and Metabolic Health, Glasgow Cardiovascular Research Centre, University of Glasgow, 126 University Place, Glasgow, G12 8TA, United Kingdom.
Bioscience reports
|September 30, 2024
概括
耐力运动员已经改善了高密度脂蛋白 (HDL) 组成,但运动不会增强健康男性的抗氧化或抗炎功能,这表明HDL的功能上限.
科学领域:
- 心血管研究研究心血管研究
- 运动生理学 运动生理学
- 脂质代谢 脂质代谢是什么
背景情况:
- 高密度脂蛋白 (HDL) 疗法未能降低心血管疾病风险,重点转移到HDL的组成和功能上.
- 运动可以恢复胰岛素耐药个体的HDL功能,但其对健康个体的影响尚不清楚.
研究的目的:
- 调查耐力运动对健康,胰岛素敏感男性高密度胆固醇 (HDL) 组成和功能的影响.
- 将耐力运动员的HDL与健康对照者的HDL进行比较.
主要方法:
- 横截面研究比较耐力运动员和健康对照.
- 通过密度梯度超离心来隔离HDL.
- 对高密度胆固醇 (HDL) 组成 (阿波利波蛋白,胆固醇,阿波利波蛋白M) 和蛋白质含量 (质谱) 的分析.
- 在内皮细胞中评估HDL抗氧化剂 (偏酶-1活性) 和抗炎功能.
主要成果:
- 与对照人群相比,耐力运动员在HDL中表现出较高的阿波利波蛋白AI和总胆固醇水平.
- 蛋白质组学揭示了运动员高血糖水平中的阿波利波蛋白A-II,A-IV,D和甲蛋白的增加.
- 两组之间没有观察到体外HDL抗氧化或抗炎功能的显著差异.
结论:
- 尽管HDL成分更有利,但耐力运动并没有增强健康男性的HDL体外抗氧化或抗炎功能.
- 这表明HDL功能可能有一个天花板,超出这个天花板,通过耐力运动无法进一步增强.
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