聚醇介导的粘合剂和抗炎双网水凝用于修复术后椎间盘缺陷
Xiaohui Zhang1, Haoxin Zhai2, Xuetao Zhu2
1Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong 250100, China.
ACS applied materials & interfaces
|September 30, 2024
概括
这项研究引入了一种新的双网水凝用于椎间盘 (IVD) 修复. 先进的水凝提供卓越的机械强度,粘合力和生物相容性,有效治疗IVD缺陷并减少炎症.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 整形外科 整形外科 整形外科
背景情况:
- 椎间盘 (IVD) 退化和缺陷带来了重大的临床挑战.
- 现有的水凝往往缺乏有效的IVD修复所需的机械强度,粘附性,生物相容性和抗炎性质.
- 开发多功能材料对于解决术后IVD缺陷至关重要.
研究的目的:
- 开发一种多功能双网络 (DN) 水凝,用于修复椎间盘 (IVD) 缺陷.
- 将高机械性能,粘附性,生物相容性,抗菌活性和抗炎作用整合到一个单一的水凝系统中.
- 评估开发的水凝在治疗术后IVD缺陷和预防的疗效.
主要方法:
- 制造双网 (DN) 水凝,使用碳素甲基 (CMCS),酸 (TA) 和烯胺 (AM).
- 物理交叉连接的CMCS/TA网络和化学交叉连接的AM网络被组合在一起.
- 评估水凝的机械性能,粘附性,生物相容性,抗菌活性和抗炎作用.
- 在IVD模型中评估水凝在封闭annulus纤维化缺陷和防止核脉变性方面的性能.
主要成果:
- 该CMCS/TA/PAM DN水凝表现出高强度,粘附性,生物相容性和抗炎性质.
- 用水凝治疗显著降低了炎症性细胞因子和与退行相关的因素.
- 水凝上调了II型原体的α1表达.
- 液凝有效地封闭了annulus纤维的缺陷,防止了细胞核的退化,保持了圆盘的高度,并部分恢复了生物力学特性.
结论:
- 开发的聚醇介导的DN水凝是IVD缺陷修复的有前途的多功能材料.
- 这种水凝有效地解决了IVD再生的关键挑战,包括机械完整性和生物反应.
- 水凝显示出在腰椎切除术后预防椎间盘的潜力.
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