卒中损伤大小与卒中后检测到的心房动之间的关联:观察性队列研究
Markus G Klammer1,2,3, Laura Reimann1,2, Oskar Richter1,2
1Center for Stroke Research Berlin (CSB) Berlin Germany.
Journal of the American Heart Association
|September 30, 2024
概括
在中风后检测到心房的患者 (AFDAS) 与没有心房 (AF) 或已知的AF (KAF) 患者相比,中风病变显著更大. 这表明AFDAS在发展中的潜在神经性作用.
科学领域:
- 神经学 神经学
- 心脏病学 心脏病学
- 脑卒中医学 脑卒中医学
背景情况:
- 在中风后检测到的心房动 (AFDAS) 是一个独特的临床实体.
- 人们认为AFDAS受到心脏和神经因子因素的影响.
- 之前的研究并没有一致地比较不同AF状态的中风病变体积.
研究的目的:
- 为了调查AFDAS患者有较大的急性缺血性中风病变的假设,与没有AF的患者和已知的AF (KAF) 患者相比.
- 探索中风病变体积和AFDAS诊断之间的关系.
主要方法:
- 预期注册1420名经MRI确认的急性缺血性中风患者.
- 划分为三个组:AFDAS,没有AF,和开放时的KAF.
- 扩散权重成像病变的手动细分,以量化病变体积.
- 统计分析包括多变量后勤回归来评估独立的关联.
主要成果:
- 与没有AF (0.7毫升) 和KAF (2.0毫升) (P<0.001) 患者相比,患有AFDAS (5.7%) 的患者的中位数损伤体积 (5.4毫升) 显著更大 (P<0.001).
- 较大的病变体积与AFDAS诊断独立相关.
- 病变体积最高的四分位数中的患者被诊断为AFDAS的可能性明显更高.
结论:
- 较大的中风病变与AFDAS诊断独立相关.
- 这些发现突出了对AFDAS.的病变发生的潜在神经性贡献.
- 在排除非血栓性病变后,这种关联仍然显著.
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