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Updated: Jun 11, 2025

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer
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Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer

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在结肠癌中,DNA不匹配修复状态和临床病理学特征之间的关系

Mehmet Doğan1, Mehmet Kılıç2, Hayriye Tatlı Doğan3

  • 1Department of Pathology, SBÜ Dr. Abdurrahman Yurtaslan Ankara Education and Research Hospital, Ankara, Türkiye.

The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
|September 30, 2024
PubMed
概括

缺少DNA不匹配修复 (MMR) 蛋白质导致微卫星不稳定 (MSI),这是林奇综合征和零星结直肠癌 (CRC) 的标志. MMR蛋白质损失与CRC患者的特定临床病理特征有关,有助于识别林奇综合征.

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Mismatch Repair01:20

Mismatch Repair

Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
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Overview of DNA Repair02:25

Overview of DNA Repair

In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
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The first step of...
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Base-pairing and DNA Repair

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