相关实验视频

Updated: Jun 11, 2025

Assessment of the Anticoagulant and Anti-inflammatory Properties of Endothelial Cells Using 3D Cell Culture and Non-anticoagulated Whole Blood

Assessment of the Anticoagulant and Anti-inflammatory Properties of Endothelial Cells Using 3D Cell Culture and Non-anticoagulated Whole Blood

Published on: September 5, 2017

在血液接触器件中的抗凝固的聚合干扰诱导的多尺度调解策略

Mingfei Pan^1,2, Zhaoyun Sun³, Yuhao Zhang⁴

¹Key Laboratory for Bio-Electromagnetic Environment and Advanced Medical Theranostics, School of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing, 211166, China.

Advanced materials (Deerfield Beach, Fla.)

|September 30, 2024

概括

最少侵入性设备可能会导致危险的血栓. 这项研究开发了一种新的涂层,通过抑制凝血因子和抵抗细胞聚合来防止凝块形成,提供了长期的解决方案.

科学领域:

生物材料科学生物材料科学
心血管研究研究心血管研究
血液静止和血栓形成

背景情况:

最少侵入性血液接触装置对于心血管疾病治疗至关重要.
与设备相关的血栓形成,特别是循环血栓形成,具有严重的危及生命的风险.
了解设备表面的初始凝血接触激活对于预防至关重要.

研究的目的:

为了研究血液接触器件外部表面的凝血接触激活的初始阶段.
为长期抗凝剂制定先进的涂层策略.
为了减轻与设备相关的血栓形成的风险.

主要方法:

直接测量力,以分析凝血因子相互作用.
活体凝血试验,以评估纤维素聚合抑制.
开发一种工程化血清蛋白涂层,其中含有zwitterion移植物和蛋白酶抑制剂协同化物.

主要成果:

激活的接触因子刺激内在凝血路径和纤维素交叉连接.
表面移植的抑制剂有效地破坏纤维素聚合.
工程涂层抵御生物沉积,并抑制凝固通路.
涂层展示了材料再生能力.

结论:

一个新的多尺度调解策略有效地抑制纳米级凝血因子.
开发的涂层可以抵抗微小的血栓聚合,提供长期的抗凝溶液.
这种方法为改善接触血液的干预设备的安全性提供了显著的潜力.

关键词:

这是一种抗凝血药物.接触血液的设备.内在路径的内在路径.多个尺度的生物力学.

更多相关视频

In Vitro Thrombosis Test for Ventricular Assist Devices

In Vitro Thrombosis Test for Ventricular Assist Devices

Published on: March 21, 2025

Artificial Lung Device Priming for In Situ Fiber Bundle Surface Grafting

Artificial Lung Device Priming for In Situ Fiber Bundle Surface Grafting

Published on: March 28, 2025

相关概念视频

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...

Venous Thrombosis III: Interprofessional Care

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...

Clot Retraction and Fibrinolysis

Clot Retraction and Fibrinolysis

After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.

Introduction to Hemostasis

Introduction to Hemostasis

Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...

Disorders of Hemostasis

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.

Coagulation

Coagulation

Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...