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臭氧耐药细菌,水回收中的不方便危险:抵抗机制,传播能力和潜在风险

Hao-Bin Wang^1,2, Yin-Hu Wu^1,2, Yige Sun^1,2

¹Environmental Simulation and Pollution Control State Key Joint Laboratory, Key Laboratory of Microorganism Application and Risk Control, Ministry of Ecology and Environment, School of Environment, Tsinghua University, Beijing 100084, PR China.

Environmental science & technology

|September 30, 2024

概括

在城市水系统中发现了耐臭氧细菌 (ORB),挑战了传统的消毒策略. 它们的耐药性源于细胞壁的特性和多糖体的出口,而不是内部酶,在传播能力上的权衡.

科学领域:

环境微生物学环境微生物学
水处理技术水处理技术.
细菌耐药性的机制

背景情况:

在城市水系统中使用消毒剂可以选择耐药细菌.
对臭氧耐药细菌 (ORB) 的了解很少,关于其耐药性机制和特征的数据有限.

研究的目的:

选和表征来自城市回收水厂的耐臭氧细菌 (ORB).
阐明ORB的抵抗机制和生理特征.
评估ORB对水处理策略的影响.

主要方法:

来自北京一家回收水厂的ORB选.
对臭氧阻力水平的比较分析.
对抗性来源的调查 (细胞外聚合物质,细胞壁,细胞内酶).
转录组分析以确定参与臭氧抵抗的关键基因.

主要成果:

六个ORB菌株被分离出来,其中三种表现出异常高的臭氧抵抗力.
细菌对臭氧的耐药性主要归因于细胞外聚合物和细胞壁的臭氧消耗能力.
转录组数据显示,在强的ORB中,蛋白质和多糖体出口基因 (例如LptF,NodJ,MetQ) 的增强转录.
观察到臭氧耐药性和细菌传播能力之间的权衡.

结论:

这项研究证实了城市水系统中存在高度抵抗臭氧的细菌.
这些发现挑战了传统的消毒控制策略,特别是那些对抗耐药细菌有效的策略.
鉴定的阻力机制和权衡效应为控制水处理中的ORB提供了潜在的途径.

关键词:

消毒消毒消毒消毒臭氧层中的臭氧.耐臭氧细菌 (ORB) 是一种耐臭氧细菌.电阻机制的电阻机制.水资源回收利用的方法

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