免疫调节障碍的移植:当前的主题和未来的期望
Susan E McClory1,2,3, Joseph H Oved4
1Program for Integrated Immunodeficiency and Cell Therapy, The Children's Hospital of Philadelphia.
Current opinion in pediatrics
|September 30, 2024
概括
造血干细胞移植 (HCT) 为儿童50多种原发性免疫调节障碍 (PIRD) 提供了治疗方法. 支持性护理和GVHD预防方面的进步提高了生存率,但患者选择仍然对最佳结果至关重要.
科学领域:
- 儿科免疫学 儿科免疫学
- 细胞疗法是一种细胞疗法.
- 移植医学 移植医学
背景情况:
- 初级免疫调节障碍 (PIRDs) 在儿科患者中越来越多地用造血干细胞移植 (HCT) 治疗.
- 现有50多种单一性PIRD,影响免疫耐受性,调节和抑制.
- 目前,对于这些多样化且往往严重的疾病来说,HCT是唯一的治疗选择.
研究的目的:
- 为儿童患者的PIRD提供HCT的最新概述.
- 讨论在这个人群中改善HCT结果的进展和未来方向.
主要方法:
- 对PIRDs的HCT当前文献的审查.
- 对疾病管理和移植技术的最新发现进行分析.
主要成果:
- 针对性治疗,GVHD预防,移植手术,调节方案和支持性护理方面的进展改善了HCT生存率.
- 高炎症状态带来诸如非移植和排斥等风险,这表明抗炎疗法的潜在益处.
- 虽然较年轻的患者具有较少的并发症,情况更好,但疾病变异性使移植决策复杂化.
结论:
- 针对PIRD的HCT是细胞治疗中的一个重要和不断增长的领域.
- 需要进一步的研究来确定最佳的患者候选人HCT,以最大限度地提高这种治疗治疗的好处.
相关概念视频
Tissue Transplantation
341
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
341
Cell-mediated Immune Responses
67.7K
Overview
67.7K
Bone Marrow Sampling and Transplants
313
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
313
Kidney Transplant I: Introduction
2
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
2
Kidney Transplant III: Nursing Management
3
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
3


