将西洛多辛和米拉贝格朗作为远端尿路结石的医疗驱逐疗法进行比较:一项前性随机研究
Mohammad Shazib Faridi1, Sanika Deshpande2
1Department of Urology, Dr Baba Saheb Ambedkar Medical College and Hospital, New Delhi, India.
Central European journal of urology
|September 30, 2024
概括
米拉贝格朗和西洛多辛显示出尿道结石的石头驱逐率相似. 然而,Mirabegron显著降低了发作,使其成为一种潜在的医疗驱逐治疗选择.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 药理学 药理学是指药理学的学科.
背景情况:
- 远端尿路结石≤10毫米是常见的,需要有效的医疗驱逐疗法 (MET).
- 米拉贝格伦和西洛多辛是MET的潜在药物,但直接比较的疗效数据有限.
研究的目的:
- 为了比较mirabegron与silodosin作为MET的疗效,用于远端尿路结石≤10毫米.
- 为了评估石头驱逐的速度,时间和疼痛发作.
主要方法:
- 预期随机试验涉及114名患有远端尿路结石≤10毫米的患者.
- 患者被随机分配到西洛多辛 (n=58) 或米拉贝格朗 (n=56) 组长达4周.
- 主要终点:石头驱逐率;次要终点:驱逐时间,疼痛发作.
主要成果:
- 在mirabegron和silodosin组之间,石头驱逐速度或时间没有显著差异.
- 米拉贝格朗组显示,发作频率显著降低 (P<0.0001).
- 在西洛多辛组的6.15%和米拉贝格朗组的3.27%报告了不良事件.
结论:
- 对于远端尿路结石,Mirabegron在石头驱逐速度或时间方面并不优于silodosin.
- 米拉贝格伦显著减少结发作,这表明它可能是一个可取的MET选择.
- 进一步的研究可能会探索mirabegron在管理与尿道结石相关的疼痛中的作用.
相关概念视频
01:25Urinary Tract Calculi VI: Surgical Management
2
Procedures for Kidney StonesMedical intervention is necessary when kidney stones or renal calculi are too large to pass spontaneously (typically greater than 5 millimeters) when stones are accompanied by symptomatic infection (such as fever or pyelonephritis), when they impair kidney function, or when they cause persistent symptoms like severe pain, nausea, or urinary retention. Additionally, patients with only one kidney or those who cannot be treated with medical management also require...
2
01:30Urinary Tract Calculi III: Medical Management
2
The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
2
01:28Urinary Tract Calculi V: Nursing Management
2
AssessmentSubjective Data: Obtain a detailed health history, including any recent or chronic urinary tract infections, periods of immobilization, previous episodes of renal calculi, and medical conditions such as gout, benign prostatic hyperplasia, or hyperparathyroidism. Review the medication history for drugs that may influence stone formation, including allopurinol, analgesics, loop diuretics, or thiazide diuretics. Document the use of long-term indwelling catheters and any past surgical...
2
01:26Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
2
Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
2
01:27Urinary Tract Calculi IV: Nutrition therapy and prevention
2
Management of renal calculi focuses on effective strategies like tailored nutrition and hydration therapy. Adjusting diet and fluid intake reduces stone formation and recurrence, making these interventions simple yet powerful in kidney stone prevention and management.Understanding Kidney StonesKidney stones form when calcium, oxalate, uric acid, and cystine concentrate and crystallize in urine. Factors contributing to their formation include genetic predisposition, certain medical conditions,...
2
01:28Urinary Tract Calculi I: Introduction
2
Renal calculi, or kidney stones, are solid deposits of minerals and salts formed inside the kidneys. In medical terminology, "calculus" refers to the stone itself, while "lithiasis" describes the process of stone formation. Depending on their location within the urinary system, these stones may be classified as either urolithiasis, when situated within the urinary tract, or nephrolithiasis, when located within the kidneys. Each term signifies the specific impact of the stone.Predisposition...
2