印度尼西亚西爪多药耐药结核病患者中药物相关负担的混合方法研究
Yudisia Ausi1, Vycke Yunivita2, Prayudi Santoso3,4
1Department of Biological Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, West Java, Indonesia.
ClinicoEconomics and outcomes research : CEOR
|September 30, 2024
概括
多药耐药结核病 (MDR-TB) 治疗造成了与药物相关的重大负担. 了解这些负担,包括疗法特征和副作用,对于改善患者的生活质量和坚持治疗至关重要.
科学领域:
- 医学研究 医学研究
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
背景情况:
- 多药耐药结核病 (MDR-TB) 构成了全球重大卫生挑战.
- 治疗MDR-TB需要复杂的,长期的治疗,往往导致与药物相关的负担.
- 这些负担可能会对患者的坚持和整体生活质量产生负面影响.
研究的目的:
- 全面调查接受MDR-TB治疗的患者所经历的与药物相关的负担.
- 通过混合方法的方法来探索这些负担的多面性质.
主要方法:
- 一项融合混合方法研究,涉及MDR-TB患者及其护理人员.
- 通过半结构化的深度访谈收集的定性数据.
- 使用经过验证的生活与药物问卷3收集的定量数据,用双变量和多变量统计数据进行分析.
主要成果:
- 定性发现强调了与药物相关的负担感知的主观性质.
- 负担的四个主要主题出现了:个人信仰,饮食,社会经济和医疗保健因素.
- 定量分析显示,较高的负担水平与较年轻的年龄组 (18-40岁) 和经历副作用 (OR=46.602) 之间存在显著的关联.
结论:
- 多抗药性结核病治疗带来了大量与药物相关的负担,特别是在治疗方案特征方面.
- 解决这些负担对于提高患者的生活质量和治疗坚持是必不可少的.
- 这些发现支持开发以患者为中心的护理策略,用于MDR-TB管理.
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