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Updated: Jun 11, 2025

Utilizing Time-Resolved Protein-Induced Fluorescence Enhancement to Identify Stable Local Conformations One α-Synuclein Monomer at a Time
07:56

Utilizing Time-Resolved Protein-Induced Fluorescence Enhancement to Identify Stable Local Conformations One α-Synuclein Monomer at a Time

Published on: May 30, 2021

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高分辨率的冷EM结构确定α-synuclein - 一个原型的粉样纤维

Juan C Sanchez1,2,3, Josh Pierson1, Collin G Borcik1,4

  • 1Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA 53706.

bioRxiv : the preprint server for biology
|September 30, 2024
PubMed
概括

这项研究详细介绍了确定α-syn纤维素 (α-syn) 纤维的高分辨率结构的协议,这对于了解帕金森病和相关的同核蛋白病变至关重要.

关键词:
阿尔法-Synuclein 的使用情况.粉样蛋白质是粉样蛋白质的蛋白质.低温电磁波冷却器 (Cryo-EM) 是一个非常好的方法.螺旋式重建螺旋式重建神经退行症的神经退行症玻璃化 玻璃化 玻璃化

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Do's and Don'ts of Cryo-electron Microscopy: A Primer on Sample Preparation and High Quality Data Collection for Macromolecular 3D Reconstruction09:25

Do's and Don'ts of Cryo-electron Microscopy: A Primer on Sample Preparation and High Quality Data Collection for Macromolecular 3D Reconstruction

Published on: January 9, 2015

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Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy14:55

Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy

Published on: September 17, 2017

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相关概念视频

Cryo-electron Microscopy01:28

Cryo-electron Microscopy

Conventional electron microscopy (EM) involves dehydration, fixation, and staining of biological samples, which distorts the native state of biological molecules and results in several artifacts. Also, the high-energy electron beam damages the sample and makes it difficult to obtain high-resolution images. These issues can be addressed using cryo-EM, which uses frozen samples and gentler electron beams. The technique was developed by Jacques Dubochet, Joachim Frank, and Richard Henderson, for...
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