侧面前额叶皮质控制工作记忆和行动之间的相互作用
Anastasia Kiyonaga1, Jacob A Miller2, Mark D'Esposito3
1University of California, San Diego.
bioRxiv : the preprint server for biology
|September 30, 2024
概括
维护工作记忆 (WM) 可以影响正在进行的行动,但大脑,特别是侧面前额叶皮质 (PFC),有助于控制这种相互作用. 不同的PFC刺激方法在这些WM机动任务期间影响主动和反应控制.
科学领域:
- 认知神经科学 认知神经科学
- 神经科学是一个神经科学.
- 发动机控制器的控制器
背景情况:
- 人类经常管理多个任务和目标,需要工作记忆 (WM) 在执行操作时保留信息.
- 积极的WM维护可以无意地影响无关的运动行为,这种现象被称为目标导向的动作干扰.
研究的目的:
- 实验调查工作记忆 (WM) 维护如何影响运动动作执行.
- 阐明横向前额叶皮层 (PFC) 在通过跨磁刺激 (TMS) 来调解WM内容和运动控制之间的相互作用中的作用.
主要方法:
- 参与者在工作记忆 (WM) 中保持方向信息的同时,执行了指导式手动.
- 在试验和区块层面上操纵了WM目标和运动目标之间的兼容性.
- 两种TMS协议 (间歇性甲型爆发和连续性甲型爆发) 应用于左侧PFC.
主要成果:
- WM维护定向信息偏向的手动轨迹和速度.
- 当WM内容可预见地与运动目标相冲突时,这种偏见减少了.
- 侧面PFC的激发性TMS损害了主动控制,而抑制性TMS损害了反应控制.
结论:
- 侧面PFC在调节工作记忆内容和手动操作之间的相互作用方面发挥着至关重要的作用.
- 侧面PFC中的不同的机制支持不同时间尺度上的适应性控制,影响主动和反应性控制策略.
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