突变的p53错误折叠和聚合预先转化为高度血清性卵巢癌

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Updated: Jun 11, 2025

Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

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Sara Sartini, Lexi Omholt, Neda A Moatamed

    bioRxiv : the preprint server for biology
    |September 30, 2024
    PubMed
    概括

    突变的p53蛋白质错误折叠和聚合是高度血清性卵巢癌 (HG-SOC) 进展的关键事件. 这种结构缺陷区分了 preneoplastic 病变和恶性 HG-SOC,这表明了治疗目标.

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