的腹侧前额叶皮层在不同的学习环境中指导决策
Atsushi Fujimoto1,2, Catherine Elorette1,2, Satoka H Fujimoto1,2
1Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029.
腹侧前额叶皮层 (vlPFC) 根据环境的新奇性来调整行为策略. 在不断变化的环境中,vlPFC 电路支持灵活的决策,影响学习和奖励处理.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 行为经济学是一种行为经济学.
背景情况:
- 适应性行为策略对于在动态环境中最大限度地获得回报至关重要.
- 腹侧前额皮层 (vlPFC) 参与概率奖励学习和决策.
- 在vlPFC介导的学习和决策中,语境的确切作用仍然不完全理解.
研究的目的:
- 调查环境环境 (新兴与熟悉的刺激) 在概率奖励学习过程中如何影响vlPFC活动和连接.
- 阐明基础上的神经机制上下文依赖的行为策略调整.
主要方法:
- 功能神经成像 (fMRI) 数据从执行概率学习任务的 rhesus macaques 中收集.
- 使用了两个不同的环境环境:新的视觉刺激和熟悉的视觉刺激.
- 用药理学操纵 (D2受体阻断) 来评估多巴胺在vLPFC功能中的作用.
主要成果:
- 在不同背景下,vlPFC活动编码的奖励结果一致.
- 行为策略 (赢-停留/输-换班) 首选在 vlPFC 中编码在新的环境中.
- 在 vlPFC 和其他大脑区域 (ACC,中脊丘脑) 之间的功能连接模式因行为策略和环境而异.
- D2受体阻塞影响了学习策略和静止状态的vlPFC活动.
结论:
- 多个vlPFC连接的电路有助于自适应性决策.
- 语境新奇性调整了vlPFC在编码和实施行为策略中的作用.
- 多巴氨基信号影响了在适应性学习和决策过程中的vLPFC功能.
更多相关视频
07:42An Automated T-maze Based Apparatus and Protocol for Analyzing Delay- and Effort-based Decision Making in Free Moving Rodents
Published on: August 2, 2018
07:08Investigating Object Representations in the Macaque Dorsal Visual Stream Using Single-unit Recordings
Published on: August 1, 2018
相关概念视频
Reason and Intuition
Role of Cerebellum and Prefrontal Cortex in Memory
Decision Making
Automatic decision-making is fast, intuitive, and relies on gut feelings...
Cognitive Learning
E. C. Tolman's theory of purposive behavior emphasizes that much behavior is goal-directed. He argued that to understand behavior, we must look at the entire sequence of actions leading to a goal. For instance, high school students study hard, not just due to past reinforcement but also to achieve the goal of getting into a good college.
Tolman introduced the idea that behavior is influenced by...
Timing and Consequences on Behavior
Humans, however, can respond to delayed reinforcers. We often make decisions between immediate small rewards and delayed larger rewards. This ability to delay gratification is a significant...
Association Areas of the Cortex
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
