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Updated: Jun 11, 2025

Studying Proteolysis of Cyclin B at the Single Cell Level in Whole Cell Populations
10:54

Studying Proteolysis of Cyclin B at the Single Cell Level in Whole Cell Populations

Published on: September 17, 2012

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针对CyclinD1-CDK4/6复杂蛋白质降解的基因模板空间控制的蛋白质溶解向

Rong Zheng, Abhay Prasad, Deeksha Satyabola

    bioRxiv : the preprint server for biology
    |September 30, 2024
    PubMed
    概括

    用DNA模板进行空间控制的PROTACs (DTACs) 为基于近距离的药物提供了高效的合成和精确的控制. 一个最佳的DTAC结构实现了CyclinD1-CDK4/6复合物的同步降解,显示出强大的抗瘤作用.

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    Experimental Approaches to Study Mitochondrial Localization and Function of a Nuclear Cell Cycle Kinase, Cdk113:15

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