相关实验视频

Updated: Jun 11, 2025

Identification of Inositol Phosphate or Phosphoinositide Interacting Proteins by Affinity Chromatography Coupled to Western Blot or Mass Spectrometry
08:07

Identification of Inositol Phosphate or Phosphoinositide Interacting Proteins by Affinity Chromatography Coupled to Western Blot or Mass Spectrometry

Published on: July 26, 2019

8.5K

伊诺西六酸盐 (InsP6) 激活HDAC1/3表观遗传轴,维持肠道屏障的功能

Sujan Chatterjee, Loretta Viera Preval, Zachary Sin

    bioRxiv : the preprint server for biology
    |September 30, 2024
    PubMed
    概括

    伊诺西聚酸盐多酶 (IPMK) 激活了基因脱乙酶 (HDAC1/3),这对基因调节至关重要. 这一发现揭示了IPMKK的发现.

    更多相关视频

    Real-time Measurement of Epithelial Barrier Permeability in Human Intestinal Organoids08:04

    Real-time Measurement of Epithelial Barrier Permeability in Human Intestinal Organoids

    Published on: December 18, 2017

    14.1K
    Using Human Induced Pluripotent Stem Cell-derived Intestinal Organoids to Study and Modify Epithelial Cell Protection Against Salmonella and Other Pathogens10:59

    Using Human Induced Pluripotent Stem Cell-derived Intestinal Organoids to Study and Modify Epithelial Cell Protection Against Salmonella and Other Pathogens

    Published on: May 12, 2019

    9.8K

    相关概念视频

    Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

    Role Of Notch Signalling In Intestinal Stem Cell Renewal

    Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
    Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
    2.1K
    Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal01:22

    Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal

    Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
    2.2K
    Renewal of Intestinal Stem Cells01:23

    Renewal of Intestinal Stem Cells

    The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
    2.5K
    Phosphoinositides and PIPs01:42

    Phosphoinositides and PIPs

    Phosphoinositides are a group of phospholipids containing a glycerol backbone with two fatty acid chains and a phosphate attached to a myoinositol sugar ring. The inositol head group extends into the cytoplasm, where it is modified by adding phosphate groups to form phosphatidylinositol phosphates or PIPs.
    Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...
    8.5K
    Inheritance of Chromatin Structures03:17

    Inheritance of Chromatin Structures

    Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
    6.2K
    Tight Junctions01:29

    Tight Junctions

    Tight junctions are molecular seals between cells that prevent the leaking of fluids, ions, and other small solutes across cavities and compartments in multicellular organisms. They are mainly composed of claudin and occludin transmembrane proteins, and other proteins such as tricellulin and JAM (junctional adhesion molecule). All these proteins are 4-pass transmembrane proteins, except JAM, which is a single-pass transmembrane protein belonging to the immunoglobulin superfamily. The...
    5.2K