通过轨道前端上下输入传感反应的预测过
Hiroaki Tsukano1,2, Michellee M Garcia1,2, Pranathi R Dandu1,2
1Department of Psychiatry, University of North Carolina at Chapel Hill; Chapel Hill, 27599, USA.
bioRxiv : the preprint server for biology
|September 30, 2024
概括
轨道前皮层 (OFC) 信号预测和抑制主要听觉皮层 (A1) 中不相关的听觉刺激. 这种自上而下的机制,涉及体静止素神经元,对于感官过和习惯至关重要.
科学领域:
- 神经科学是一个神经科学.
- 听觉感知是一种听觉感知.
- 感官处理 感官处理
背景情况:
- 习惯是一种关键的感官过过程.
- 习惯性失调与感官过载障碍有关.
- 习惯的神经基础,包括预测信号和涉及的大脑区域,仍然不完全理解.
研究的目的:
- 为了确定负责习惯性的内部预测模型的大脑位置.
- 阐明在听觉皮层中传感过的基础上的电路机制.
- 研究轨道前皮层 (OFC) 在听觉习惯中的作用.
主要方法:
- 在动物模型中,轨道前皮层 (OFC) 失活.
- 在初级听觉皮层 (A1) 中的电生理学记录 (A1).
- 从前部区域,特别是腹侧OFC.上下投影的分析.
主要成果:
- 在A1.1中,OFC的无活化逆转了每日神经习惯.
- 来自腹侧OFC的自上而下的预测,而不是其他额头区域,传达了预测信号.
- 这些预测信号随着听觉经验的增加而增加,并通过体静止素抑制神经元抑制A1活动.
结论:
- 轨道前皮层 (OFC) 在听觉习惯中发挥着至关重要的作用.
- 来自腹侧OFC的预测信号对于抑制A1中无关的感官输入至关重要.
- 这种由OFC介导的自上而下的机制产生了预期刺激的"负面图像",有助于感官过.
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