从电子健康记录数据构建一个多状态模型,用于建模长期糖尿病并发症
Riza C Li1,2, Shanshan Ding2,3, Kevin Ndura1
1iREACH, ChristianaCare Health Services, Inc., Newark, DE, USA.
Journal of clinical and translational science
|September 30, 2024
概括
糖尿病患者由于长期并发症而面临生活质量的下降. 多州建模揭示了较高的微血管并发症率,并将社会经济劣势与风险增加联系起来.
科学领域:
- 糖尿病研究研究 糖尿病研究
- 公共卫生 公共卫生
- 生物统计学 生物统计学
背景情况:
- 长期糖尿病并发症显著损害生活质量.
- 了解糖尿病相关不良结果的进展对于患者护理至关重要.
研究的目的:
- 用多状态建模方法评估糖尿病患者的不良结果.
- 根据临床概况分析糖尿病并发症的进展情况.
主要方法:
- 对10,596名糖尿病患者 (2013-2017) 的回顾性研究.
- 利用五个状态模型来追踪并发症的进展.
- 纳入了高维共变量和社会经济数据 (面积贫困指数).
主要成果:
- 患者的微血管 (0.1334) 与大血管 (0.0508) 并发症的发生率更高.
- 处于较弱势地区的患者出现并发症的比率更高.
- 5,928名患者没有出现并发症,而另一些患者患有微血管,大血管或两者兼而有之.
结论:
- 多状态建模为分析糖尿病并发症进展提供了一个全面的框架.
- 确定了影响糖尿病并发症发展和进展的关键因素.
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