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皮下脂肪微环境作为多囊性卵巢综合征中体脂发育的决定因素

Daniel A Dumesic¹, Melody A Rasouli¹, Jessica D Katz¹

¹Department of Obstetrics and Gynecology, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Journal of the Endocrine Society

|September 30, 2024

概括

在患有多囊性卵巢综合征 (PCOS) 的女性中,皮下脂肪阿尔多基托减少酶1C3 (AKR1C3) 蛋白表达,以及脂肪细胞分化和雄激素受体标志物,预测脂肪积累. 这一发现对于理解PCOS体脂发育至关重要.

科学领域:

内分泌学在内分泌学.
代谢障碍代谢障碍代谢障碍
生殖健康生殖健康

背景情况:

脂肪组织的类固醇代谢在体内脂肪的发展中起作用,特别是在多囊性卵巢综合征 (PCOS) 中.
阿尔多基因减酶1C3 (AKR1C3) 是脂肪组织内丸激素生成的标志物.

研究的目的:

为了调查皮肤下 (SC) 腹部脂肪AKR1C3是否在正常体重的女性中增加,与对照组相比.
确定SC腹部脂肪AKR1C3,激活蛋白-1 (AP-1;脂肪细胞分化的标志物) 和雄激素受体 (AR) 蛋白表达在预测脂肪积累中的关系.

主要方法:

一项前性队列研究,涉及18名患有PCOS的正常体重女性和17名匹配对照.
测量包括循环激素,葡萄糖耐受性,通过DXA进行体脂分布,以及使用免疫组织化学进行蛋白质表达分析的SC腹部脂肪活检 (AKR1C3,AP-1,AR).

主要成果:

患有PCOS的女性有较高的血清雌激素和雌激素/雌激素脂肪比率. 在不同组之间,SC脂肪AKR1C3,AP-1和AR蛋白的表达是相似的.
在PCOS中,AKR1C3与脂肪质量正相关,与AP-1负相关. AR与自由脂肪酸和HDL负相关.
在这两组中,AKR1C3与皮质醇水平有负相关性.

结论:

在患有PCOS的正常体重女性中,SC腹部脂肪AKR1C3蛋白表达,以及脂肪内AP-1和AR-依赖的通路,预测脂肪积累.
这些发现突显了脂肪类固醇代谢在PCOS相关脂肪分布中的作用,特别是在生理皮质醇条件下.

关键词:

激活蛋白-1-1是一种激活蛋白.脂肪的脂肪的脂肪阿尔多 - 基因减少酶 1C3 受体受体是受体的受体.皮质醇是一种皮质醇.多囊性卵巢综合征多囊性卵巢综合征

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