差差分化甲状腺癌患者生存的动态估计:基于人口的研究
Zhao Liu1, Qianlan Xu2, Heng Xia1
1Department of Breast and Thyroid Surgery, Shaoxing Central Hospital, The Central Affiliated Hospital, Shaoxing University, Shaoxing, China.
Frontiers in endocrinology
|September 30, 2024
概括
这项研究引入了一种新方法,以动态估计差分甲状腺癌 (PDTC) 患者的存活率. 开发的CS-nomogram提高了长期PDTC幸存者的实时生存预测.
科学领域:
- 在瘤学瘤学.
- 医学统计 医学统计
背景情况:
- 对差差分化甲状腺癌 (PDTC) 幸存者的预后数据有限.
- 对PDTC患者的实时生存估计需要新的方法.
研究的目的:
- 使用一种新的方法,动态估计PDTC患者的存活率.
- 为实时PDTC生存预测开发和验证一个条件生存 (CS) -nomogram.
主要方法:
- 使用了913名PDTC患者的数据 (2014-2015年SEER数据库).
- 采用卡普兰-梅尔总生存率 (OS) 方法和计算的CS率.
- 使用LASSO回归用于预测器识别和多变量考克斯回归用于CS-nomogram开发.
主要成果:
- 卡普兰-梅尔分析显示3,5年和10年的OS率分别为83%,75%和60%.
- 条件生存 (CS) 分析显示,随着时间的推移,生存概率逐渐增加.
- 建立并验证了一种新的CS-nomogram,包含11个重要的预测因素.
结论:
- 这是第一个分析长期PDTC幸存者的CS模式的研究,显示了随着时间的推移而改善的生存率.
- 开发的CS-nomogram提供了个性化的,动态的,实时的生存预测.
- 该CS-nomogram使临床医生能够根据不断变化的风险改进量身定制的治疗策略.
相关概念视频
Cancer Survival Analysis
329
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
329
Kaplan-Meier Approach
104
The Kaplan-Meier estimator is a non-parametric method used to estimate the survival function from time-to-event data. In medical research, it is frequently employed to measure the proportion of patients surviving for a certain period after treatment. This estimator is fundamental in analyzing time-to-event data, making it indispensable in clinical trials, epidemiological studies, and reliability engineering. By estimating survival probabilities, researchers can evaluate treatment effectiveness,...
104
Actuarial Approach
63
The actuarial approach, a statistical method originally developed for life insurance risk assessment, is widely used to calculate survival rates in clinical and population studies. This method accounts for participants lost to follow-up or those who die from causes unrelated to the study, ensuring a more accurate representation of survival probabilities.
Consider the example of a high-risk surgical procedure with significant early-stage mortality. A two-year clinical study is conducted,...
Consider the example of a high-risk surgical procedure with significant early-stage mortality. A two-year clinical study is conducted,...
63
Comparing the Survival Analysis of Two or More Groups
156
Survival analysis is a cornerstone of medical research, used to evaluate the time until an event of interest occurs, such as death, disease recurrence, or recovery. Unlike standard statistical methods, survival analysis is particularly adept at handling censored data—instances where the event has not occurred for some participants by the end of the study or remains unobserved. To address these unique challenges, specialized techniques like the Kaplan-Meier estimator, log-rank test, and...
156
Assumptions of Survival Analysis
101
Survival models analyze the time until one or more events occur, such as death in biological organisms or failure in mechanical systems. These models are widely used across fields like medicine, biology, engineering, and public health to study time-to-event phenomena. To ensure accurate results, survival analysis relies on key assumptions and careful study design.
101
Introduction To Survival Analysis
188
Survival analysis is a statistical method used to study time-to-event data, where the "event" might represent outcomes like death, disease relapse, system failure, or recovery. A unique feature of survival data is censoring, which occurs when the event of interest has not been observed for some individuals during the study period. This requires specialized techniques to handle incomplete data effectively.
The primary goal of survival analysis is to estimate survival time—the time...
The primary goal of survival analysis is to estimate survival time—the time...
188


