胸腺癌患者的心血管疾病
Abhishek Khemka1, Suparna C Clasen1, Patrick J Loehrer2
1Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, United States.
Frontiers in cardiovascular medicine
|September 30, 2024
概括
胸腔癌患者面临更高的心脏事件风险,特别是那些接受治疗的先前存在疾病患者. 放射治疗和化疗显著增加高风险患者的心脏事件发生率.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 癌症患者患有心脏不良事件的风险增加.
- 胸腺癌患者的心血管风险尚不清楚.
- 基线心脏代谢风险因素和治疗对心脏事件的影响需要表征.
研究的目的:
- 在胸腺癌患者中描述基线心脏代谢风险因素.
- 评估胸腺癌治疗与随后的心脏事件之间的关联.
主要方法:
- 追溯队列研究,将胸腺癌患者 (TCP) 与非癌症对照患者 (2003-2020) 进行比较.
- 收集了基线心血管风险因素,癌症特征和心脏事件的数据.
- 多变量回归分析用于评估风险因素和癌症疗法.
主要成果:
- 与对照组相比,TCP的心脏事件发生率更高 (HR1.38,p=0.042).
- 高风险的TCP (≥2个风险因素或先前存在的心血管疾病) 显示显著增加心脏事件风险 (HR 3.73,p<0.001).
- 高风险TCP的放射治疗或化疗进一步增加了心脏事件的风险 (HR 4.99,p<0.001;HR 6.24,p<0.001).
结论:
- 胸腔癌患者的心脏事件比对照患者多,即使经过风险因素调整.
- 患有多种心血管风险因素的患者接受放射治疗或化疗时,心脏事件的风险要高得多.
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