非侵入性闭环声学脑电脑接口用于控制发作
Junjie Zou1,2, Houminji Chen1,2, Xiaoyan Chen2,3
1The National Key Clinic Specialty, The Engineering Technology Research Center of Education Ministry of China, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.
Theranostics
|September 30, 2024
概括
这项研究引入了一种新型的非侵入性声学脑电脑接口 (aBCI),可以使用EEG检测发作开始,并通过迷走神经超声刺激终止发作.
科学领域:
- 神经科学是一个神经科学.
- 生物医学工程 生物医学工程
- 医疗器械 医疗器械
背景情况:
- 大脑-计算机接口 (BCI) 对于理解大脑至关重要.
- 对于BCI的进步,需要使用非侵入性神经调节技术.
- 的治疗需要创新的,非侵入性的解决方案.
研究的目的:
- 开发和评估一种非侵入性的闭环声学脑电脑接口 (aBCI).
- 使用脑电图 (EEG) 解码发作开始并触发迷走神经刺激.
- 评估aBCI在终止鼠模型中发作的疗效.
主要方法:
- 开发了一种aBCI系统,用于实时检测EEG发作发作.
- 在老鼠模型中,利用迷走神经的超声波刺激来终止发作.
- 通过RT-qPCR研究了潜在的控制机制.
主要成果:
- 该aBCI系统成功地通过迷走神经超声波刺激检测了发作开始和结束的发作.
- 超声波刺激激活了结节质神经元,并抑制了海马/杏仁体的兴奋性.
- 与传统的电动迷走神经刺激相比,aBCI显示出更好的抗效果.
结论:
- 闭环aBCI提供了一种新,安全和有效的方法来治疗异常的神经元放电.
- 这项技术是迈向下一代非侵入性BCI的重要一步.
- aBCI使和潜在的其他神经系统疾病的需求神经调节成为可能.
相关概念视频
01:10Control Systems
Control systems are everywhere in contemporary society, influencing diverse applications from aerospace to automated manufacturing. These systems can be found naturally within biological processes, such as blood sugar regulation and heart rate adjustment in response to stress, as well as in man-made systems like elevators and automated vehicles. A control system is essentially a network of subsystems and processes that collaboratively convert specific inputs into desired outputs.
At the heart...
At the heart...
01:17Open and closed-loop control systems
Control systems are foundational elements in automation and engineering. They are broadly categorized into open-loop and closed-loop systems. These classifications hinge on the presence or absence of feedback mechanisms, significantly influencing the system's performance, complexity, and application.
An open-loop control system operates without feedback from the output. It consists of two primary elements: the controller and the controlled process. The controller receives an input signal and...
An open-loop control system operates without feedback from the output. It consists of two primary elements: the controller and the controlled process. The controller receives an input signal and...