在看似健康的患者中预测动脉硬的年龄特定方法
Anna Bragina1,2, Yulia Rodionova1,2, Natalia Druzhinina1,2
1Department of Internal Medicine No. 2, Institute of Clinical Medicine, Sechenov First Moscow State Medical University, 19991 Moscow, Russia.
Journal of clinical medicine research
|September 30, 2024
概括
与年龄相关的心血管指数 (CAVI) 值更好地预测50岁以下的个体的动脉硬. 对于50岁及以上的人来说,普遍的CAVI值显示了对动脉硬的更高预测值.
科学领域:
- 心脏病学 心脏病学
- 血管生物学 血管生物学
- 预防医学 预防医学
背景情况:
- 心血管疾病 (CVD) 风险因素在没有被诊断为CVD的个人中很普遍.
- 动脉硬是心血管疾病发展的关键预测因素和机制.
- 预测未来的心血管事件对于预防策略至关重要.
研究的目的:
- 为了比较与年龄相关的预测准确度与检测动脉硬性的普遍心血管指数 (CAVI) 参考值.
- 在没有心血管疾病的个体中确定最佳的CAVI风险分层值.
- 为了向临床实践提供有关对动脉硬性的评估的信息.
主要方法:
- 一项涉及600名参与者的研究 (43%是男性,57%是女性,平均年龄为36.0±18.3岁).
- 评估包括人体测量测量,肥胖标志物和通过血计评估动脉硬度.
- 预测模型使用了与年龄相关的 (CAVI年龄) 和普遍的 (CAVI ≥9.0) 值.
主要成果:
- 在50岁以下的参与者中,CAVI年龄模型显示出较高的灵敏度,特异性和AUC (0.802) 与CAVI ≥9 (AUC 0.674) 相比.
- 在50岁以上的参与者中,CAVI ≥9模型显示AUC (0.787) 比CAVI年龄模型 (AUC 0.675) 高.
- 这两种模型都是各自年龄段动脉硬的重要预测因素.
结论:
- 特定年龄的CAVI值在预测50岁以下人群的动脉硬方面更有效.
- 一个普遍的CAVI值 (≥9.0) 对于预测50岁及以上个体的动脉硬性更有利.
- 根据年龄组量身定制CAVI评估可以改善动脉硬的检测,并为心血管风险管理提供信息.
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