与阿尔茨海默氏症疾病中的肠道失调症相关的炎症表现
Samat Kozhakhmetov1, Aiym Kaiyrlykyzy1,2, Zharkyn Jarmukhanov1
1Center for Life Sciences National Laboratory Astana Nazarbayev University, Astana, Kazakhstan.
International journal of Alzheimer's disease
|September 30, 2024
概括
这项研究揭示了哈萨克斯坦阿尔茨海默病 (AD) 患者肠道微生物组的明显变化,包括较低的Firmicutes/Bacteroidetes比率和减少的Bifidobacterium. 这些变化与特定的炎症标志物相关,并可能提供新的AD生物标志物.
科学领域:
- 微生物学 微生物学
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
背景情况:
- 新出现的证据将肠道微生物组失调与阿尔茨海默氏症 (AD) 病原发生联系起来.
- 在不同种族的AD患者报告的肠道微生物概况中存在显著差异,需要进一步调查.
- 由肠道微生物群驱动的外周炎症被假定有助于零星的AD发展.
研究的目的:
- 分析阿尔茨海默病的哈萨克斯坦个体的肠道微生物特征.
- 探索肠道微生物群,血液细胞因子和AD患者的临床参数之间的关联.
- 为了识别AD诊断和治疗的潜在微生物和炎症特征.
主要方法:
- 在哈萨克斯坦,涉及被诊断患有阿尔茨海默病的个体的横截面研究设计.
- 使用16S rRNA测序对肠道微生物组成的分析.
- 血液中细胞因子和相关临床参数的分析.
主要成果:
- 阿尔茨海默病患者的Firmicutes/Bacteroidetes比率降低,Bifidobacterium的丰度降低,包括B. breve.
- 在AD患者中观察到 Pseudomonadota (例如,Phyllobacterium),Synergistetes和Christensenellaceae家族的增加存在.
- 在阿尔茨海默病患者中检测到增加的促炎细胞因子 (IL-1a,IL-8,IL-17A,TNF-β) 和抗炎细胞因子 (IL-10,IL-13).
- 发现了细胞因子,血清腺素和特定微生物种群之间的显著相关性.
结论:
- 该研究在一个种族多样化的AD队列中确定了独特的肠道微生物和炎症特征.
- 肠道微生物群的变化,包括特定的细菌种群和代谢途径,与AD相关.
- 这些发现表明潜在的微生物生物标志物和基于微生物群的阿尔茨海默病治疗点.
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