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食道癌与口腔微生物组之间的因果关系:基于亚洲人口的孟德尔随机化研究
Keke Hu1, Ting Huang1, Yiming Zhang2
1Department of Oncology, Hangzhou Traditional Chinese Medicine (TCM) Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Frontiers in cellular and infection microbiology
|September 30, 2024
概括
这项研究使用了门德尔的随机化来探索口腔微生物群和食道癌 (EC) 之间的因果关系. 结果显示出双向关系,表明了基于微生物组的查和EC治疗的潜力.
科学领域:
- 微生物组研究的研究.
- 在瘤学瘤学.
- 遗传学 遗传学 是一个
背景情况:
- 人们怀疑口腔微生物和食道癌 (EC) 之间的相互作用是可疑的,但尚未完全理解.
- 之前的研究表明潜在的交叉通话,需要进一步调查因果关系.
研究的目的:
- 研究口腔微生物组的变化与食道癌 (EC) 的发展之间的因果关系.
- 使用门德尔随机化 (MR) 来确定口腔微生物变化和EC之间的因果关系.
主要方法:
- 进行了双向门德尔随机化 (MR) 分析.
- 使用了来自4D-SZ队列 (口腔微生物组) 和日本 (EC) 生物银行 (BioBank) 的全基因组关联研究 (GWAS) 数据.
- 为了验证,进行了多种灵敏度分析 (科克兰的Q,MR-Egger拦截,MR-PRESSO).
主要成果:
- 在73个口腔微生物组和EC之间发现了统计学上显著的因果关系,其中38个被确定为保护性.
- 涉及的关键类型包括菌,Patescibacteria和Actinobacteria.
- 像Parvimonas micra,Aggregatibacter和Clostridia这样的特定物种显示出与EC的负因果关系;Periodonticum_C,未分类_mgs_3234和未分类_mgs_45显示出与EC的强烈因果关系.
结论:
- 在口腔微生物组和食道癌 (EC) 之间存在双向因果关系.
- 这些发现为开发基于微生物组的早期查工具提供了新的见解.
- 这些结果支持针对口腔微生物群的益生菌疗法在EC管理中的潜在应用.
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