跨波长校准方法用于实时成像组织光学特性,使用频域扩散光学光谱学
Thao Pham1, Lina Lin Wei1, Darren Roblyer1
1Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, MA 02215, USA.
Biomedical optics express
|September 30, 2024
概括
我们开发了一种新的交叉波长校准 (CWC) 方法,用于频域扩散光学光谱 (FD-DOS) 成像. 这种技术提高了准确性,并减少了组织光学性质测量的工件,增强了临床应用.
科学领域:
- 生物医学光学 生物医学光学
- 医疗成像医学成像
- 频谱学是一种光谱学.
背景情况:
- 频域扩散光学光谱 (FD-DOS) 对于非侵入性组织光学性质评估至关重要.
- 现有的方法可能对光学合变化和运动工件敏感.
- 实时组织表征需要强大而准确的测量技术.
研究的目的:
- 引入和验证用于FD-DOS的新型横波长校准 (CWC) 方法.
- 提高组织光学性质测量的准确性和可靠性.
- 与传统方法相比,简化FD-DOS仪器,降低成本.
主要方法:
- 开发了集成到TrackDOSI实时FD-DOS成像系统中的CWC方法.
- 使用固体幻影验证了CWC方法.
- 在幻影和人体组织上测试了CWC方法,以评估文物抑制和可重复性.
主要成果:
- CWC方法与幻影的黄金标准自校准 (SC) 方法有很强的一致性 (-10%吸收,1%减少散射).
- 证明有效地抑制运动工件和光学合变异.
- 在动态成像中提高了测量可重复性,信号保真性和文物校正.
结论:
- CWC方法提供了一个比传统的SC方法更简单,更强大,更具成本效益的替代方案.
- 在具有挑战性的条件下,CWC提高了FD-DOS测量的准确性和可靠性.
- 这种技术具有显著的潜力,可以提高扩散光学光谱成像的临床效用.
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