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在用水凝间隔器进行低剂量速率支臂疗法时,雄激素剥夺的好处
Koyo Kikuchi1, Shuhei Ishii2, Yoshiro Ieko1
1Department of Radiation Oncology, Iwate Medical University, Morioka, JPN.
Cureus
|September 30, 2024
概括
雄激素剥夺疗法 (ADT) 与水凝间隔器放置 (HSP) 结合,可显著降低前列腺支架治疗中的直肠剂量. 这种组合在降低直肠剂量特别有效,在直肠的下部部分.
科学领域:
- 辐射瘤学 辐射瘤学
- 尿道瘤学 尿道瘤学
- 医学物理 医学物理
背景情况:
- 前列腺癌的治疗通常涉及低剂量率 (LDR) 支臂疗法.
- 直肠剂量是影响毒性和治疗结果的关键因素.
- 基剥夺疗法 (ADT) 和水凝间隔器放置 (HSP) 是减轻直肠剂量的策略.
研究的目的:
- 评估ADT和HSP在前列腺癌LDR支臂治疗期间对直肠剂量减少的影响.
- 评估不同直肠段 (高,中,低) 的剂量降低疗效.
主要方法:
- 对接受I-125 LDR支臂治疗的130名患者的回顾性分析.
- 患者根据ADT使用 (ADT与非ADT) 和HSP使用 (HSP与非HSP) 进行分类.
- 在HSP前后分析了直肠体积 (RV) 和分段RV (sRV) 剂量 (RV100).
主要成果:
- 在非ADT患者中,HSP在高和中段显著降低了直肠剂量,但在低段没有.
- 在ADT患者中,HSP在所有三个部分 (高,中,低) 显著降低了直肠剂量.
- 在HSP和非HSP队列中,在ADT和非ADT组之间没有观察到直肠剂量的显著差异.
结论:
- ADT和HSP的结合表明,在LDR前列腺支架治疗中,具有显著的直肠剂量降低潜力.
- 当与ADT同时使用时,HSP在降低直肠剂量方面特别有效,特别是在下方直肠段.
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