益生菌对伴随抑郁症的肥胖的影响:系统性审查和元分析
Liang Chen1, Jinhu Zhou1, Ting Xu1
1Department of Endocrinology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China.
British journal of hospital medicine (London, England : 2005)
|September 30, 2024
概括
益生菌并没有显著改善肥胖成年人的抑郁症. 然而,它们在使用爱丁堡产后抑郁量表和短期使用肥胖相关抑郁症时显示出好处.
科学领域:
- 临床营养学 临床营养学
- 精神病学是一个精神病学.
- 微生物组研究 微生物组研究
背景情况:
- 肥胖和抑郁症经常与双向关系同时发生.
- 益生菌正在研究其治疗肥胖和相关抑郁症的潜力.
- 目前关于治疗肥胖相关抑郁症的益生菌的证据不一致.
研究的目的:
- 系统地评估益生菌在改善肥胖成年人的抑郁症状方面的疗效.
- 使用元分析综合随机对照试验 (RCT) 的发现.
主要方法:
- 在PubMed,EMBASE,Web of Science和RCTs的Cochrane图书馆进行系统的文献搜索.
- 使用随机效应模型对抑郁症得分的元分析.
- 评估异质性 (I2),出版偏差 (漏斗图,Begg/Egger测试) 和敏感性分析 (子组,GOSH,离开一个).
主要成果:
- 包括五个RCT (n=488);总的来说,益生菌没有显著改善抑郁症状 (MD = 0.08,p=0.82).
- 观察到显著的异质性 (I2=63%).
- 亚组分析显示,益生菌在爱丁堡产后抑郁症量表 (MD = -0.60,p=0.04) 上改善了抑郁症得分,没有异质性,并在服用补充剂12周后 (MD = -0.78,p=0.05).
结论:
- 益生菌在改善肥胖个体的抑郁症状方面没有显示出整体疗效.
- 针对特定的抑郁症尺度 (爱丁堡产后抑郁症尺度) 和短期益生菌使用,注意到了潜在的益处.
- 需要进一步严格的RCT来确认益生菌对与肥胖相关的抑郁症的治疗潜力.
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