在童年细菌性脑膜炎后的神经系统后果
Laura Lempinen1,2, Riste Saat3,4, Sakke Niemelä5
1HUS Medical Imaging Center, Radiology, University of Helsinki and Helsinki University Hospital, PB 340, 00029 HUS, Helsinki, Finland. laura.j.lempinen@hus.fi.
European journal of pediatrics
|September 30, 2024
概括
儿童细菌性脑膜炎 (BM) 仍然是一个重大威胁,死亡率显著,以及长期的神经后果,如失语症/失色症. 尽管取得了进展,但在BM幸存者中这些结果的危险因素尚未确定.
科学领域:
- 儿科 儿科 儿科
- 传染性疾病 传染性疾病
- 神经学 神经学
背景情况:
- 细菌性脑膜炎 (BM) 继续构成严重的死亡风险和严重的后果,尽管医学的进步.
- 肺炎链球菌和脑膜炎菌被确定为主要的细菌病原体,负责儿童BM.
研究的目的:
- 评估儿童细菌脑膜炎的发病率,临床表现,病原体,诊断和结果.
- 评估与儿科BM相关的神经后果,听力损失和死亡率.
- 确定BM儿童死亡的潜在风险因素,不良结果和长期神经系统后果.
主要方法:
- 在2010年至2020年期间在高等儿童中心诊断出BM的儿科患者的回顾性审查.
- 使用格拉斯哥结果尺度 (GOS) 来分类结果,得分1-4表示不利的结果.
- 使用后勤回归单变量分析来确定不利结果的风险因素.
主要成果:
- 这项研究包括74名患者 (77个BM发作),平均BM发病率为2.2/100,000/年,主要是社区获得的 (91%).
- 肺炎链球菌和脑膜炎菌是最常见的病原体 (分别为16%).
- 在长期随访中,在32%的幸存者中观察到神经后果,阿法西亚/失声症是最常见的 (17%);9%的患者死亡,3%的患者有听力损失.
结论:
- 细菌性脑膜炎 (BM) 仍然具有显著的死亡风险.
- 很大比例的BM幸存者经历了持续的神经后果,特别是听力障碍 / 听力障碍,3%发展出听力损失.
- 没有独立的风险因素被确定为预测长期的神经后果在这个队列.
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