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Updated: Jun 11, 2025

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A Novel Method: Super-selective Adrenal Venous Sampling
Published on: September 15, 2017
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"非功能"上腺偶发性瘤中的心脏代谢并发症和心血管事件:系统性审查和元分析
Vittoria Favero1,2, Chiara Parazzoli2, Davide Paolo Bernasconi3,4
1Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, 20100, Italy.
Journal of endocrinological investigation
|September 30, 2024
概括
患有非功能性上腺意外瘤 (NFAI) 的患者表现出动脉高血压 (AH) 和代谢综合征 (MS) 的风险增加. 这一系统性审查发现,与对照组相比,NFAI与AH,复合糖尿病 (C-DM) 和MS的更高患病率有关.
科学领域:
- 内分泌学 在内分泌学.
- 心血管医学 心血管医学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 非功能性上腺瘤 (NFAI) 是偶然发现的上腺瘤.
- NFAI与代谢和心血管并发症之间的关联需要进一步研究.
研究的目的:
- 在患有NFAI的患者中,确定动脉高血压 (AH),糖尿病 (DM),复合性DM (C-DM),失脂血症 (DL),代谢综合征 (MS) 和心血管事件 (CVE) 的患病率.
- 将这些患病率与没有上腺意外瘤 (AI) 的对照人群进行比较.
主要方法:
- 系统审查和对现有文献进行元分析.
- 包括19项研究,涉及4716名受试者.
- 随机效应模型用于计算聚合赔率比率 (OR) 和95%置信区间 (95%CI).
主要成果:
- NFAI与AH (OR1.87),C-DM (OR2.04) 和MS (OR2.89) 的更高患病率显著相关.
- 在NFAI和DM,DL或CVE之间没有发现显著的关联.
- 最初选了36项研究的数据,19项研究提供了用于元分析的数据.
结论:
- 与没有NFAI的患者相比,NFAI患者的AH,C-DM和MS的患病率更高.
- NFAI可以作为心血管风险因素增加的指标.
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