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儿童群体中的库辛综合征:谁以及如何查
Laura Chioma1,2, Giuseppa Patti3,4, Marco Cappa5
1Endocrinology and Diabetology Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Journal of endocrinological investigation
|September 30, 2024
概括
库辛格 (Cushing) 的意思是说,库辛格.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 内分泌学 在内分泌学.
- 内部医学 内部医学
背景情况:
- 库希综合征 (CS) 是由于长时间暴露于过多的葡萄糖皮质类药物造成的.
- 在儿童中,从葡萄糖皮质类药物治疗中产生的外源性CS是常见的;内源性CS很少见 (10%).
- 儿童内源性CS通常依赖ACTH (垂体瘤) 或由上腺产生.
研究的目的:
- 审查儿童患者库辛综合征的原因和诊断挑战.
- 突出儿童CS的关键临床特征和诊断工作.
主要方法:
- 对儿童内源性和外源性库辛综合征的文献综述.
- 分析病因因素,临床表现和诊断策略.
主要成果:
- 下垂体ACTH分泌瘤是儿童内源性CS的最常见原因 (75-80%).
- 上腺原因占儿科内源性CS病例的15-20%.
- 由于潜伏性发病和非特异性早期症状,诊断具有挑战性.
结论:
- 在儿童中早期识别CS需要意识到微妙的临床症状,如生长不良和面部变化.
- 鉴于个别查方法的不完全准确性,确认高皮质醇症需要结合诊断测试.
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