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对T细胞受体谱的计算分析工作流程:从T细胞隔离到生物信息学分析

Roberta Amoriello1, Olfa Maghrebi2, Clara Ballerini2

  • 1Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy. roberta.amoriello@unifi.it.

Methods in molecular biology (Clifton, N.J.)
|September 30, 2024
PubMed
概括

用高通量测序分析T细胞受体 (TCR) 谱系多样性,这对于适应性免疫至关重要. 生物信息学方法对于从大型数据集中理解TCR特征至关重要.

关键词:
衰老的衰老 衰老的衰老生物信息学是一种生物信息学.疾病 疾病 疾病高通量测序的高通量测序在TCR的曲目中,TCR的曲目包括:

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Overview Of Cell Separation And Isolation01:20

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Cell separation was first achieved in 1964 by S. H. Seal, who separated large tumor cells from the smaller blood cells using filtration. Two years later, Pohl and Hawk performed experiments on how cells respond differently to a nonuniform electric field based on the cell type. Such observations were the inception of cell separation methods, which allow isolating a single cell type from a heterogeneous sample.