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Updated: Jun 11, 2025

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在晚期前列腺癌中确定雄激素受体变异合成的拼接因子要求

Laura Walker1, Ruaridh Duncan1, Beth Adamson1

  • 1Newcastle University Centre for Cancer, Newcastle upon Tyne, United Kingdom.

Molecular cancer research : MCR
|September 30, 2024
PubMed
概括

鉴定雄激素受体变体 (AR-V) 拼接的调节者对于克服前列腺癌治疗耐药性至关重要. 这项研究确定了MFAP1和CWC22作为AR-V生成的关键拼接因子,为割抵抗性前列腺癌提供了新的治疗点.

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