选择性和口服生物可用的c-Met PROTACs用于治疗c-Met成的癌症

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Updated: Jun 11, 2025

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Shilong Ying1, Hongli Chi1, Xiaoqiu Wu1

  • 1The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China.

Journal of medicinal chemistry
|September 30, 2024
PubMed
概括

一种新型的蛋白质分解向嵌合体 (PROTAC),Met-DD4,在癌细胞中有效降解c-Met. 这种有针对性的降解显示出对治疗c-Met成癌症的承诺,毒性最小.

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