2000年至2017年间诊断的临床阶段乳腺癌特定死亡趋势
Michal Marczyk1,2, Adriana Kahn2, Andrea Silber2
1Department of Data Science and Engineering, Silesian University of Technology, Gliwice, Poland.
Journal of the National Cancer Institute
|September 30, 2024
概括
早期乳腺癌 (I期和II期) 现在导致超过60%的乳腺癌死亡,尽管预后良好. 需要新的策略来识别和治疗患有复发风险的早期患者,以进一步降低乳腺癌死亡率.
科学领域:
- 在瘤学瘤学.
- 癌症研究 癌症研究
- 公共卫生 公共卫生
背景情况:
- 转移性乳腺癌每年导致大约4万例死亡.
- 了解不同疾病阶段对乳腺癌死亡率的贡献,对于公共卫生战略至关重要.
研究的目的:
- 确定每年因I,II,III和IV期疾病而导致的乳腺癌特定死亡人数的比例.
- 分析这些比例的时间趋势随着时间的推移.
主要方法:
- 利用了来自监测,流行病学和最终结果 (SEER) 计划 (1975-2017) 的数据.
- 包括972,763名符合特定标准的患者 (女性,单一的原发性瘤,手术,AJCC第6版阶段>0,没有双边癌症,生存数据).
- 使用线性模型和ANOVA测试评估时间趋势.
主要成果:
- 在2000年至2017年期间,第一阶段和第二阶段癌症对乳腺癌死亡的贡献显著增加 (分别为16.2%至23.1%和30.7%至39.5%).
- 在同一时期,第三阶段和第四阶段癌症的贡献下降了 (分别从36.4%降至30.3%和16.7%降至7.1%).
- 结节阴性T1a,T1b和T1c癌症的死亡人数也显著增加,对于激素受体阳性和阴性癌症观察到的类似趋势.
结论:
- 尽管预后很好,但第一阶段和第二阶段的乳腺癌现在占乳腺癌特定死亡人数的60%以上,因为它们的发病率很高.
- 需要有效的策略来识别和治疗患有复发风险的I期和II期患者,以进一步降低乳腺癌死亡率.
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