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通过调节cGAS-STING信号传输来减轻辐射性结肠炎

Qian Xue¹, Haoqiang Lai¹, Haimei Zhang¹

¹Department of Radiation Oncology of Puning People's Hospital, Department of Chemistry of Jinan University, State Key Laboratory of Bioactive Molecules and Druggalibility Assessment, MOE Key Laboratory of Tumor Molecular Biology, Jinan University, Guangdong, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

|September 30, 2024

概括

纳米颗粒 (SeNPs) 为放射性结肠炎提供了一个有前途的治疗方法. 通过减少炎症,DNA损伤和氧化应激,SeNPs可以防止肠道损伤,为放射治疗患者提供希望.

科学领域:

在瘤学瘤学.
辐射疗法辐射疗法
胃肠病学胃肠病学

背景情况:

辐射性结肠炎是盆腔放射治疗的常见并发症,没有有效的临床治疗方法.
迫切需要新的治疗药物来管理辐射诱导的肠道损伤.

研究的目的:

研究 (Se) 和纳米颗粒 (SeNPs) 对辐射结肠炎的保护作用.
阐明SeNPs在减轻辐射诱导的肠道损伤方面的潜在分子机制.

主要方法:

在放射性大肠炎模型中评估X射线诱导的亡,细胞循环停止和炎症.
对活性氧物种生成和DNA损伤反应的分析.
对干扰素基因 (STING) -TBK1-IRF3信号通路的循环GMP-AMP合成酶 (cGAS) -刺激器的研究.
评估单蛋白表达 (例如GPX4) 以及其对肠道免疫力和肠道微生物群的影响.

主要成果:

,特别是SeNPs,通过抑制细胞亡,细胞循环停止和炎症,表现出保护作用.
SeNPs有效地平衡了反应性氧物种的产生,并抑制了DNA损伤反应,减少了肠道损伤.
这种SeNP抑制了cGAS-STING-TBK1-IRF3通路,阻断了炎症性细胞因子 (IL-6,TNF-α) 转录.
在体内SeNP治疗诱导了蛋白表达,调节了肠道免疫力和调节了肠道微生物群,减轻了辐射性结肠炎.

结论:

纳米颗粒代表了对辐射结肠炎的新治疗策略.
通过诱导蛋白表达和抑制cGAS-STING-TBK1-IRF3级联,SeNP产生保护作用,从而减轻氧化应激和炎症.

关键词:

造成的DNA损伤是DNA损伤.这就是ROSOS ROS.cGAS-STING 的使用情况.辐射大肠炎的原因是一种.

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