相关实验视频

Updated: Jun 11, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

自主造血干细胞移植用于系统性硬化症相关的间歇性肺部疾病

Jana Zielonka¹, Jean Paul Higuero Sevilla

¹Yale School of Medicine, Department of Internal Medicine, Section of Pulmonary, Critical Care and Sleep Medicine, New Haven, Connecticut, USA.

Current opinion in rheumatology

|September 30, 2024

概括

自主造血干细胞移植 (HSCT) 对扩散性皮肤性全身性硬化症 (dcSSc) 显示出希望,可能稳定或改善SSc相关间歇性肺病患者的肺功能.

科学领域:

免疫学免疫学免疫学
类风湿病学类风湿病学
肺部病理学肺部病理学

背景情况:

扩散性皮肤全身性硬化症 (dcSSc) 是一种严重的自身免疫性疾病.
系统性硬化症 (SSc) 相关的间歇性肺病 (ILD) 是SSc患者的主要死亡原因.
自主造血干细胞移植 (HSCT) 已成为dcSSc.的潜在治疗选择.

研究的目的:

审查目前关于HSCT在治疗dcSSc中的作用的证据,特别关注dcSSc相关的ILD.
解决关于dcSSc和ILD的HSCT有效性和安全性的剩余问题和局限性.

主要方法:

对dcSSc.的HSCT临床试验和观察性研究的审查.
报告肺部结果的分析,包括肺功能测试和成像结果.
考虑患者选择标准和研究限制.

主要成果:

虽然肺部结果通常是次要的,并且严重肺功能障碍的患者被排除在外,但证据表明HSCT可以稳定或改善dcSSc中的ILD.
与dcSSc.的常规治疗相比,HSCT已经证明了优越的长期结果.

结论:

与标准疗法相比,HSCT为dcSSc提供了更好的长期结果.
进一步的研究对于优化患者选择,调节方案和探索dcSSc中HSCT的维持免疫抑制是必不可少的.
考虑到其高死亡率,加强对SSc相关的间歇性肺病管理的重视至关重要.

更多相关视频

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome

Published on: October 3, 2018

Author Spotlight: Exploring the Lifespan Dynamics of Healthy Human Hematopoiesis

Author Spotlight: Exploring the Lifespan Dynamics of Healthy Human Hematopoiesis

Published on: December 8, 2023

相关概念视频

Bone Marrow Sampling and Transplants

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...

Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...

iPS Cell Differentiation

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.