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患有糖尿病前期患者结肠直肠癌的长期风险:综合系统性审查和元分析

Praneeth Reddy Keesari1, Akhil Jain2, Yashwitha Sai Pulakurthi3

  • 1Department of Internal Medicine, Staten Island University Hospital, Staten Island, New York, USA. . drpraneethkeesari@gmail.com.

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糖尿病前期患者患结直肠癌 (CRC) 的风险增加了16%. 早期查和生活方式的改变对于管理糖尿病前期和降低CRC风险至关重要.

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科学领域:

  • 代谢健康和瘤学
  • 流行病学和公共卫生.

背景情况:

  • 糖尿病前期经常没有被诊断出来,超过80%的人无症状地患上糖尿病.
  • 新出现的证据表明,糖尿病前期和癌症发病率增加之间存在联系,特别是结肠直肠癌 (CRC).

研究的目的:

  • 系统地审查和对糖尿病前期患者结直肠癌发病率的现有证据进行元分析.
  • 量化糖尿病前期和CRC风险之间的关联.

主要方法:

  • 在主要数据库 (PubMed,Embase,Scopus,Google Scholar) 进行了全面的文献搜索,直到2022年6月.
  • 使用二进制随机效应模型的元分析,包括子组和灵敏度分析 (留出一个).
  • 研究的质量是使用纽卡斯尔-太华尺度来评估的.

主要成果:

  • 包括7项前性研究和1项后性研究,包括15个队列和100多万参与者.
  • 在糖尿病前期患者中观察到CRC几率的统计显著增加 (调整后OR=1.16;95%CI,1.08至1.25).
  • 在前性研究和5至10年的随访期中,这种关联更为强烈.

结论:

  • 前糖尿病与患结直肠癌的可能性增加了16%.
  • 改变生活方式 (饮食,运动,减肥) 对于糖尿病前期管理至关重要.
  • 建议在患有糖尿病前期的高风险个体进行有针对性的CRC查.