选择药用植物的体外生物活动及其协同效应
K Gnaneswari1, Ch M Kumari Chitturi1, K R Padma1
1Department of Applied Microbiology, Sri Padmavati Mahila Visvavidyalayam, Tirupati, India.
Pakistan journal of pharmaceutical sciences
|September 30, 2024
概括
克罗顿勃兰地 (Croton bonplandianus) 和蒂索尼亚多叶 (Tithonia diversifolia) 提取物的协同作用组合显示出强大的抗菌,抗氧化和抗炎作用. 这种植物协同效应显示出开发针对传染病原体的新治疗方法的前景.
科学领域:
- 植物化学 植物化学
- 药理学 药理学是指药理学的学科.
- 微生物学 微生物学
背景情况:
- 自然产品是生物活性化合物的丰富来源.
- 克罗顿邦普兰迪亚努斯 (Croton bonplandianus) 和蒂索尼亚多叶植物 (Tithonia diversifolia) 是传统上使用的药用植物.
- 研究协同效应可以增强治疗潜力.
研究的目的:
- 为了评估Croton bonplandianus和Tithonia diversifolia甲醇提取物的植物化学特征.
- 评估单个提取物及其协同作用组合的抗微生物,抗氧化和抗炎活性.
- 探索这些植物在打击传染病方面的潜力.
主要方法:
- 使用标准协议进行植物化学查.
- 试验室试验包括对抗微生物活性的光盘扩散,对抗氧化能力的DPPH和总抗氧化剂试验,以及对抗炎症活性的HRBC膜稳定和抗蛋白质变性试验.
- 综合提取物的协同效应评估 (CbTd).
主要成果:
- 协同作用的CbTd提取物对测试细菌表现出强大的抗菌活性,最大抑制区为21毫米.
- CbTd表现出显著的抗氧化活性,低IC50为7.64毫克/毫升,优于单个提取物.
- 在CbTd提取物中观察到高百分比的血液溶解 (93%) 和蛋白质变性 (69%) 的抑制,这表明它具有强大的抗炎性质.
结论:
- 克罗顿勃兰地 (Croton bonplandianus) 和蒂索尼亚多叶 (Tithonia diversifolia) 提取物的协同作用组合显著增强了抗菌,抗氧化和抗炎作用.
- 这种协同效应表明,在对抗人类传染病原体的配方中,CBTd具有有前途的治疗潜力.
- 需要进一步研究这种协同作用背后的特定化合物和机制.
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