减轻与年龄相关的认知衰退和记忆缺陷通过阿波莫尔芬的管理
Huma Ikram1, Rumaisa Zakir2, Darakhshan Jabeen Haleem3
1Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Pakistan.
Pakistan journal of pharmaceutical sciences
|September 30, 2024
概括
在老鼠中,阿波莫尔芬治疗逆转了与年龄相关的记忆力下降和氧化应激. 这表明阿波莫尔芬可能是治疗老年痴呆症和相关疾病的有希望的疗法.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 药理学 药理学是指药理学的学科.
背景情况:
- 氧化应激,由反应性氧物种驱动,加速衰老.
- 与年龄相关的认知衰退与神经炎症和降低抗氧化剂防御有关.
- 阿波莫尔芬是治疗神经退行性疾病 (如帕金森病和阿尔茨海默病) 的关键药物.
研究的目的:
- 研究阿波莫尔芬在老老鼠中的神经保护和增强记忆的作用.
- 评估阿波莫尔芬对氧化应激标志物和衰老中的认知功能的影响.
主要方法:
- 雄性Albino Wistar大鼠 (4个月和24个月大) 每天在六天内接受腹腔内注射阿波莫尔芬.
- 评估了氧化应激标志物的大脑和血水平 (氨酸过氧化酶,超氧化物脱氧化酶,催化酶,脂质过氧化).
- 评估了短期和长期记忆,乙胆酶 (AChE) 活性和大脑生物原氨酸水平.
主要成果:
- 老老鼠表现出抗氧化酶活性降低和脂质过氧化增加,阿波莫芬逆转了这种情况.
- 在老老鼠中,阿波莫尔芬的使用恢复了认知功能,并使ACHE活动正常化.
- 用阿波莫尔芬治疗使老老鼠大脑中的生物氨基和代谢物水平正常化.
结论:
- 阿波莫尔芬有效地减轻氧化压力,并改善老老鼠的记忆障碍.
- 这些发现支持阿波莫尔芬作为治疗年龄相关认知障碍 (包括痴呆症) 的治疗剂的潜力.
- 剂量为1mg/kg的阿波莫尔芬在治疗老年人痴呆症和相关疾病方面显示出有前途.
更多相关视频
07:07Analysis of Learning and Memory Ability in an Alzheimer's Disease Mouse Model using the Morris Water Maze
Published on: October 29, 2019
19.0K
08:01Intracerebroventricular Injection of Amyloid-β Peptides in Normal Mice to Acutely Induce Alzheimer-like Cognitive Deficits
Published on: March 16, 2016
42.1K
相关概念视频
01:22Alzheimer's Disease: Treatment
170
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
170
01:30Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
106
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
106
01:26Alzheimer's Disease: Overview
451
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
451
01:24Parkinson's Disease: Treatment
233
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
233
01:30Cognitive Development During Adulthood
65
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
65
01:23Role of Neurotransmitters in Memory
466
Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
466