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Updated: Jun 11, 2025

Preparation of Neutrally-charged, pH-responsive Polymeric Nanoparticles for Cytosolic siRNA Delivery
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Preparation of Neutrally-charged, pH-responsive Polymeric Nanoparticles for Cytosolic siRNA Delivery

Published on: May 2, 2019

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一种新型的,无毒的奇托桑,经过素修改,以提高siRNA输送的缓冲能力

Tianhui Liu1, Mei Lin2, Chengfei Zhao1

  • 1Department of Pharmacy, School of Pharmacy and Medical Technology, Putian University, Putian, China/Key Laboratory of Pharmaceutical Analysis and Laboratory Medicine in University of Fujian Province, Putian University, Putian, China.

Pakistan journal of pharmaceutical sciences
|September 30, 2024
PubMed
概括

这项研究开发了一种新型的基托衍生物 (LGCS),使用素进行有效的siRNA传递. LGCS表现出改善的特性和高转染效率与低毒性,使其成为一个有前途的基因载体.

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Delivery of Therapeutic siRNA to the CNS Using Cationic and Anionic Liposomes

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相关概念视频

siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
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