激进前列腺切除术后男性的丸激素疗法用于低中间器官受限前列腺癌
Jose M Flores1,2, Emily A Vertosick2, Carolyn A Salter1,2
1Sexual & Reproductive Medicine Program, Urology Service, Memorial Sloan Kettering Cancer Center, New York, New York.
The Journal of urology
|September 30, 2024
概括
对于前列腺癌的激进前列腺切除术后的丸激素治疗不会增加生化复发率. 这项研究没有发现任何证据表明替代疗法会导致选择患者的癌症复发.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
背景情况:
- 对于前列腺癌,激进前列腺切除术 (RP) 后的治疗 (TTh) 是有争议的.
- 在RP后出现丸激素缺乏症的男性需要仔细考虑TTh.
研究的目的:
- 评估TTh对RP后生化复发率 (BCR) 的影响.
- 评估TTh安全性在男性低中介性器官受限前列腺癌.
主要方法:
- 对接受RP的5199名男性进行了回顾性分析.
- 考克斯模型与T使用的时间依赖共变量,调整为临床因素.
- 里程碑式的分析是在RP后18周开始的,PSA无法检测.
主要成果:
- 198名患者接受了T后RP;5001人没有.
- T组有更多的血管并发症.
- 与TTh (HR 0.84,P = 0.5) 相关的BCR风险没有显著下降 (HR 0.84,P = 0.5).
- 在两组中,5年BCR概率<2%.
结论:
- 对于RP后的男性,TTh可以安全地给予选择性男性.
- 在这个队列中,没有证据表明TTh在RP后增加BCR.
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