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Updated: Jun 26, 2026

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提取细胞内β-粉样纤维聚合物的提取,用于研究分子水平的结构传播,使用固态NMR光谱学

June M Kenyaga1, Wei Qiang1

  • 1Department of Chemistry, Binghamton University, the State University of New York, Vestal, New York 13850, United States.

Biochemistry
|September 30, 2024
PubMed
概括

这项研究通过控制粉样β (Aβ) 纤维化来优化阿尔茨海默病研究的活体播种协议. 新的工作流程将非种子纤维化最小化,确保Aβ纤维的精确结构多态分析.

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Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...
Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...