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固体器官移植接受者的皮肤状细胞癌:当前的治疗和查策略
Ann-Kristin Struckmeier1, Martin Gosau1, Ralf Smeets2
1Department of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany.
Transplantation reviews (Orlando, Fla.)
|September 30, 2024
概括
固体器官移植接受者 (SOTR) 面临更高的癌症风险,特别是皮肤状细胞癌 (CSCC). 管理需要多学科的护理,在SOTR中使用免疫疗法需要仔细考虑,因为潜在的风险.
科学领域:
- 在瘤学瘤学.
- 移植医学 移植医学 移植医学
- 皮肤病学 皮肤病学
背景情况:
- 固体器官移植接受者 (SOTRs) 的恶性瘤风险增加,皮肤状细胞癌 (CSCC) 带来了重大挑战.
- 在SOTR中,CSCC通常呈现为具有高转移潜力的多重瘤,导致与普通人群相比生存率较差.
研究的目的:
- 审查SOTR中CSCC目前的治疗和查策略.
- 强调免疫治疗在这种患者群体中的作用和考虑.
主要方法:
- 文献审查侧重于SOTRs中的CSCC管理.
- 对移植后CSCC的查,治疗和免疫治疗数据的分析.
主要成果:
- 在SOTR中进行CSCC管理需要采用多学科的方法.
- SOTRs通常被排除在临床试验之外,限制了免疫检查点抑制剂 (ICI) 的数据.
- 大多数SOTR中的ICI数据来自病例系列,突出了安全性和有效性问题.
结论:
- 针对性查和治疗途径对于患有CSCC的SOTRs至关重要.
- 在考虑ICI之前,应探索替代疗法,因为会有异位移植排斥的风险.
- 需要进一步的研究,以建立对SOTRs的安全有效的免疫治疗方案.
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