在高风险人群中部癌症查的热点:关于免费提供,最佳方法,自我抽样和独立风险因素的临床研究
Edoardo Virgilio1,2, Carlo Salvemini3, Maria Grazia Treglia4
1Department of Medicine and Surgery, University of Parma, Parma, Italy; edoardo.virgilio@unipr.it.
Anticancer research
|September 30, 2024
概括
建议进行免费的门癌症查 (ACS),高分辨率的透视镜与活检和巴普查是最有效的方法. 超重个体面临更高的风险,突出了需要可访问的查计划.
科学领域:
- 在瘤学瘤学.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 全球门癌 (AC) 发病率正在上升,但由于证据不足,缺乏标准化查 (ACS).
- 大多数高风险人群缺乏对必要的查程序的财政支持.
- 意大利公共卫生服务部门资助了一项研究,以评估最佳的ACS方法.
研究的目的:
- 为高风险人群确定最有效的门癌症查方法.
- 评估公开资助的免费ACS计划的可行性和影响.
- 为了确定癌的风险因素和预防措施.
主要方法:
- 接受性交或有宫发育不良史的个人进行自愿查.
- 一级ACS包括数字检查,异视镜检查,帕普检查和HPVDNA测试 (自我和临床医生采样).
- 2级查使用高分辨率无光镜 (HRA),带有或没有活检 (HRAB).
主要成果:
- 招募了50名高风险人群;在艾滋病毒阳性MSM中检测到1例AC.
- 在10名MSM中发现了高度状内皮损伤 (HSIL),在13名参与者中发现了低度 (LSIL).
- 高分辨率透视透视与活检 (HRAB) 结合巴普查检查显示出更高的灵敏度,特异性和准确性. 门自取样 (ASS) HPV DNA 测试的结果与临床医生采样相似.
结论:
- 一个公共资助的,免费的门癌症查计划是合理的和推的.
- 带有活检 (HRAB) 的高分辨率异视镜和巴氏涂片是最有效的查工具.
- 超重被认为是该人口中门癌症的重要危险因素.
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