在新辅助化疗后对头部和部状细胞癌的临床病理学审查
Ryosuke Kuga1,2, Kazuki Hashimoto3, Hidetaka Yamamoto4
1Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Anticancer research
|September 30, 2024
概括
对头部和部状细胞癌 (HNSCC) 的新辅助化疗 (NAC) 可能导致低估瘤大小,可能影响手术边缘. 切除计划应依赖于NAC前成像,而不是治疗后评估.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 头部和部癌症研究研究
背景情况:
- 新辅助化疗 (NAC) 对头部和部状细胞癌 (HNSCC) 的疗效尚未得到充分证实.
- 在NAC后准确评估瘤大小对于手术规划至关重要.
研究的目的:
- 评估HNSCC患者对NAC的病理反应.
- 将基于成像的瘤大小与NAC后的病理测量进行比较.
- 为了确定NAC对外科切除边缘的影响.
主要方法:
- 对30名HNSCC患者的回顾性分析,这些患者在NAC.之后接受了彻底切除.
- 治疗反应和残留瘤模式的病理评估.
- 从成像与病理学的最大水平直径的比较.
主要成果:
- 其余的瘤模式包括缩小 (10),混合 (11),和碎片 (7) 类型.
- 在NAC后成像中低估瘤大小是常见的,特别是在多焦点病变中.
- 低估与较高的积极或接近外科手术边缘发生率相关.
结论:
- 减少切除体积的NAC策略对于HNSCC不是最佳的.
- 手术边缘的评估应基于NAC前的成像.
- 准确的手术前分期对于成功的HNSCC治疗结果至关重要.
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