nociceptor 主性有助于机械 nociceptive 值和炎症和神经病痛疼痛
Lindsey A Fitzsimons1,2, Larissa Staurengo-Ferrari3, Eugen V Khomula3
1Deparment of Biomedical Sciences, College of Osteopathic Medicine, University of New England, Biddeford, Maine 04005.
概括
nociceptors 中的主要毛囊控制疼痛敏感性和神经病痛. 破坏这些结构可以减少疼痛和过敏症,突出显示它们的治疗潜力.
科学领域:
- 神经科学是一个神经科学.
- 细胞生物学 细胞生物学
背景情况:
- 初级毛是基于微管的器官,对神经发育和成年神经元功能至关重要.
- 它们在痛感神经元 - - 痛感受体中的存在和功能在很大程度上仍未被探索.
- 对于 nociceptor 敏感化至关重要的刺信号,已知是主要依赖于纤毛的.
研究的目的:
- 为了研究大鼠恶感受体中初级毛的存在和功能.
- 确定初级乳毛在机械疼痛值,炎症性疼痛和化疗诱导的神经病痛 (CIPN) 中的作用.
主要方法:
- 在老鼠感受体体中确立了初级毛的存在.
- 使用的siRNA向肌内运输 (IFT) 蛋白质 (Ift88,Ift52),以破坏初级毛.
- 在体内评估了机械感受值和体内评估了感受刺激能力.
- 对前列腺素E2 (PGE2) 和帕克利塔塞尔诱导的CIPN.评估的疼痛反应.
- 通过使用环胺,调查了对 Hedgehog 信号的作用.
主要成果:
- 主要毛存在于 nociceptor somata 中,并影响机械疼痛敏感性.
- 主性眼的干扰减弱了PGE2诱导的过敏症和帕克利塔塞尔诱导的CIPN,以性别特定的方式.
- 击败IFT蛋白质废除了过敏症和CIPN,证实了初级毛的作用.
- 刺信号抑制也减少了CIPN,支持其参与.
结论:
- 鼻受体初级毛是机械疼痛感觉的关键调节者.
- 这些毛在炎症和神经病痛中发挥着重要作用,特别是依赖子的CIPN.
- 准 nociceptor 主性乳毛是治疗疼痛的潜在治疗策略.
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