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Updated: Jul 20, 2026

A Parasite Rescue and Transformation Assay for Antileishmanial Screening Against Intracellular Leishmania donovani Amastigotes in THP1 Human Acute Monocytic Leukemia Cell Line
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通过深层蛋白质组学来表征莱什马尼亚婴儿诱导的对三价性糖酸盐 (SbIII) 的耐药性

Adriana Castillo-Castañeda1, Luz H Patiño2, Antonio Muro3

  • 1Centro de Investigaciones en Microbiología y Biotecnología-UR (CIMBIUR), Facultad de Ciencias Naturales, Universidad del Rosario, Bogotá, Colombia; Infectious and Tropical Diseases Research Group (e-INTRO), Biomedical Research Institute of Salamanca-Research Centre for Tropical Diseases at the University of Salamanca (IBSAL-CIETUS), Faculty of Pharmacy, University of Salamanca, 37008 Salamanca, Spain.

Journal of proteomics
|September 30, 2024
PubMed
概括

这项研究揭示了Leishmania婴儿寄生虫如何对关键的抗药物 - - 固醇酸产生抗性. 耐药寄生虫显示出参与能量,新陈代谢和基因表达的蛋白质水平发生变化,提供了新的治疗点.

关键词:
能量补偿是指能量补偿.L. 婴儿的婴儿.脂质生物合成 脂质生物合成过氧体生物发生.定量化蛋白质基因的研究.RNA代谢的RNA代谢过程斯蒂博格卢康酸耐药性

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Leishmaniasis

Leishmaniasis is a protozoal disease caused by species of the genus Leishmania and transmitted through the bite of infected female sandflies. The parasite exists in two principal morphological forms during its life cycle. A sandfly acquires intracellular amastigotes from an infected reservoir host, such as a dog. Within the sandfly, these forms differentiate into motile, flagellated promastigotes. During a subsequent blood meal, promastigotes are injected into the human host, where they...
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Antiprotozoal Agents

Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...