癌症和左心房扩大在患有缺血性中风的患者
Morin Beyeler1, Anokhi Pawar2, Eric Buffle3
1Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute and Department of Neurology, Weill Cornell Medicine, New York, USA; Graduate School for Health Sciences, University of Bern, Switzerland; Department of Neurology, Inselspital, Bern University Hospital and University of Bern, Switzerland.
概括
这项研究在缺血性中风患者中没有发现活跃癌症和心房心脏病之间的联系. 需要进一步的研究来探索潜在的癌症-心房病理学联系.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 神经学 神经学
背景情况:
- 癌症诊断与心房的更高风险有关.
- 心房心脏病,一种增加缺血性中风风险的疾病,也是一个令人担忧的问题.
- 癌症和心房心脏病之间的关系尚不清楚.
研究的目的:
- 在急性缺血性中风患者中调查活跃癌症和心房心脏病之间的关联.
- 在未确定来源的栓塞性中风 (ESUS) 患者的小组中探索这一关联.
主要方法:
- 对1104名急性缺血性中风住院患者进行了回顾性横截面研究.
- 暴露:活跃的癌症. 结果:心房心脏病变 (左心房体积指数≥35mL/m2).
- 对ESUS患者进行多变量逻辑回归和子组分析.
主要成果:
- 在整体队列中,没有发现活跃癌症和心房心脏病之间的显著关联 (aOR,0.91;95% CI,0.60-1.37).
- 在ESUS小组中没有观察到任何关联 (aOR,0.64;95% CI,0.30-1.36).
- 扩大暴露以包括任何癌症史也显示没有显著的关联 (aOR,0.93;95% CI,0.68-1.25).
结论:
- 根据左心房体积,癌症与缺血性中风患者的心房心脏病不相关,包括ESUS患者.
- 使用不同的心房心脏病生物标志物和在其他临床环境下进行进一步的研究是有必要的.
- 癌症和心房心脏病之间的潜在联系需要进一步调查.
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