在自身免疫诊断中,关于切断设置的尖端混乱
Jan Damoiseaux1, Hetty Bontkes2, Leontine Mulder3
1Central Diagnostic Laboratory, Maastricht University Medical Center, Maastricht, the Netherlands..
Autoimmunity reviews
|September 30, 2024
概括
自身免疫诊断依赖于切线值,但它们的各种确定方法阻碍了结果的协调. 本综述探讨了切断值的确定及其对解释自身免疫性疾病测试结果的影响.
科学领域:
- 临床免疫学 临床免疫学
- 诊断试验的发展.
- 自身免疫性疾病诊断 自身免疫性疾病诊断
背景情况:
- 自免疫诊断解释结果使用切断值来分类测试结果 (负到强阳性).
- 目前确定这些截止值的方法非常异质.
- 这种异质性阻碍了不同试验和公司测试结果的协调.
研究的目的:
- 描述和讨论用于确定自身免疫诊断中切断值的各种方法.
- 突出不同截止值确定策略对测试结果解释的影响.
- 在临床实践中提高对临界值"混矩阵"的认识.
主要方法:
- 关于在诊断试验中确定切线值的方法的文献综述.
- 对自身免疫性疾病的诊断和分类标准的分析,这些诊断和分类标准参考了切线值.
- 讨论截止值波动对测试协调和临床解释的影响.
主要成果:
- 在用于确定自身免疫诊断测试的切断值的方法中存在显著的异质性.
- 尽管存在这种异质性,但自身免疫性疾病的诊断和分类标准往往指的是协调的特定切断值.
- 缺乏标准化的切线建立有助于混的解释测试结果.
结论:
- 截止值确定标准化对于提高自身免疫诊断测试的可靠性和可比性至关重要.
- 对于临床医生和研究人员来说,了解确定截止值的各种方法至关重要.
- 解决截止值的"混矩阵"对于准确诊断和分类自身免疫性疾病是必要的.
相关概念视频
01:29Autoimmune Disorders
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Concept and Mechanism of Autoimmune Diseases
The immune system...
01:15Receiver Operating Characteristic Plot
A ROC (Receiver Operating Characteristic) plot is a graphical tool used to assess the performance of a binary classification model by illustrating the trade-off between sensitivity (true positive rate) and specificity (false positive rate). By plotting sensitivity against 1 - specificity across various threshold settings, the ROC curve shows how well the model distinguishes between classes, with a curve closer to the top-left corner indicating a more accurate model. The area under the ROC curve...